发给老马备查:
+ Q% O" {+ E, ~6 K2 C# r0 B滴水察海(69304838) 15:23:23
! L4 U4 N* r' P老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱
& D, n1 s6 F5 j吉非替尼和S-1连用的依据4 e* B) A- O% }/ h) M# t- O
Gefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.1 g) E3 P \$ {3 r) Z U
是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达
, w; f! |+ N0 g# h8 I R/ b$ j5 ~, t9 ?这样是不是推理出,耐药后,可以用S-1和培美了?8 t7 \. T4 e! l9 ^2 _4 A' }
结论:
0 }1 L$ \) s. ^. c如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |